Thanks for all the great insight on TSX for buffalo. Since I will also be hunting leopard and only taking one rifle, my 416 Remington , I am wondering what you all think about using the 400 grain TSX on leopard. I have read Dr Roberson, who says they won't expand enough. I so far have only shot one coyote with this load in the rib cage . I wish I would have pulled back the fur to see the exact size of the hole, but as it was it only looked like maybe the size of a quarter , the coyote dropped and got up and ran about 50 feet before giving up the ghost. a much different result from the 350 grain Speer hot core which completely removed the contents of his rib cage. I am thinking of using the Northfork 400 grain PP on the leopard if I can get them to group the same as the TSX.