I've killed about twice as many elk (I think 21) with 180 gr Nosler Partitions as I've killed with all other bullets combined. I've killed most of my deer, pronghorn antelope, and mountain sheep with 117 gr Sierra GameKing bullets.
On my first African hunt, I shot all my animals with 7mm Nosler Ballistic Tip bullets. That was a spur of the moment trip for me, and in the very limited time I had to work up a load, the Ballistic Tips were more accurate in my rifle than Partitions.
A few years after my first African hunt, I found an accurate load for my 7mm Rem mag with 160 gr Accubonds and I used them on a Canadian caribou and muskox hunt (remember enysse?), and then for a half dozen antelope on another South African hunt.
When I booked my Zimbabwe buffalo hunt I needed a larger rifle so I built a .375 RUM. With this new rifle I decided to try new bullets, and to eliminate the soft/solid dilemma, I decided to try the 300 gr TSX bullets. I got good accuracy in my rifle with these bullets, and in Africa, they performed very well on my buffalo and on several plains game animals.
In 2007 I hunted the Eastern and Southern Cape regions of South Africa and decided to only take one rifle. Because I would be hunting eland and kudu, I took my .375 RUM with 270 gr TSX bullets which were also very accurate in my rifle. These TSX bullets performed very well on the 13 animals that I shot with them, and I believe on that trip I also made my closest ever (eland @ 30 yds) and longest ever (gemsbok @ 348 yds) one shot kills with a rifle.
About 4 years ago I built a rifle that I had been dreaming about since the 70s, a .300 Weatherby. Because I had experienced good results with TSX bullets in my .375 RUM, I decided to try them in my new .300 Wby. Both 168 gr and 180 gr TSX bullets grouped sub moa in this rifle, and I decided to use the 168s on this rifle's maiden hunt for exotics in west Texas. I also used a 168 gr TSX that fall on a Montana bull elk and beside the almost instantaneous kill, the TSX bullet produced only a fraction of the amount of bloodshot tissue compared to the large amount of bloodshot tissue from the 180 gr Partitions on previous elk that I had shot.
I had planned on taking my .300 Weatherby on my South African hunt last summer, and when I was loading shells for practice and to take on that trip, I ran out of 168 gr TSX bullets. I went to our local sporting goods store for more 168 gr TSX bullets, but all thay had were 168 gr TTSX bullets, so I bought 2 boxes of them. These TTSX bullets shot 3 shot one ragged hole groups in my rifle, so I decided to use them in Africa. These 168 gr TTSX bullets made virtually instantaneous one shot kills on the 5 animals that I shot with them including a baboon at 290 yds and a klipspringer at 314 yds.
So the point of this reply is that I've used a variety of bullets, including Nosler Partitions, on a good number of North American and African game animals and basically what I have found is: If the bullet is designed for hunting, and it is accurate in my rifle, and I do my part and put it into an animals boiler room, I will put meat in the freezer and/or my taxidermist will keep busy.