Based on your ( very sound ) reasoning , l would say .416 Remington. Ooo , l know. A .458 Lott ? I always wanted one of those. Currently my only DG rifle is a .375 HH Magnum anywayyes it might, but at what cost, and then how well?
there are alternatives for that action that would be idiotproof, just a new barrel and go shoot.
when you think about it, the place to start is the bullet.
diameter, weight(s), construction, and velocity.
then you go to a delivery system, namely the case, design, capacity.
then you go to the action that will handle all that reliably, and the twist to stabilize the longest bullet you will shoot.
then the style and weight etc of the gun.
also availability of components, with as many choices as possible for different jobs and increased availability.
getting cases and bullets at your local gunshop, or in the mail sure makes life easier.
using these criteria, how does the 416 rem (can make cases from 375 easily in a pinch) compare to the 10.75x68?