I shoot a 500 NE with no problemsI was also concerned about heavy recoil on my 458 Lott and an Reflex sight guys shooting pistol competition shooting over 1000 rounds per weekend don't have any issues and that is a slide that slides back hard and fast then comes to adrubt stop when loaded.
I am sure the recoil on that is much more severe going backwards and forwards all the time while the rifle only has backward recoil.
The Issue I have seen is the mounting system not the sight that is the weakest link.
If the mounting system is good you will be good with a reflex sight.