Since I have never hunted DG, my opinion has far from the same value as the ones from an experienced DG hunter like
Mike70560
But my question is how many Buffs have been lost or have charged the hunter because he used a 375 and not something bigger, when the hunter has put a high quality bullet in the right place.
My guess is none.
Buffs are lost or charge because the hunter has either used a shit bullet or because he didn't put the bullet where it should be.
If you shoot a 416 or something bigger as well as a 375, then get that if that is what you want.
But if your accuracy gets affected, even if it is very slightly, then you should just buy a 375 in my opinion.
I have a 375 Ruger and I didn't buy it to hunt DG as I don't think I ever will have the money for it.
But if I should win enough money to hunt Buffalo and even Elephant, I would without hesitation bring my 375 Ruger and feel 100% confident about it.
I feel 100% sure I will be able to put the bullet where it needs to be with that gun.