Winchester availability could possibly be an issue for some. I ordered one in M70 Alaskan in 338 WM 18 months ago. I'm still waiting for it to grace our Canadian shores.
One thing I know already is that I need a new rifle since a buffalo is my main goal. But I still will need something suitable for a plains game hunt.
the .458 Winchester Mag is the same price and I am tempted to go all Dirty Harry here and go for the biggest gun I can get!