I’ve taken six elk with 225gr Core Lokts in my .338WM. One shot kills but NOT at distance! The longest was 150 yards. I prefer to hunt the edges and wide openings next to heavy timber. They do seem to penetrate well and the two bullets I recovered stayed intact with good mushrooming. So whether they’ll work at 400yds, don’t know? Don’t really know why I started using them in the first place, except they used to be inexpensive, but now they cost more than the Barnes TSX! I’m leaning towards the Barnes as no meat contamination from the lead?