This is very interesting. The .416s didn't even break 3000. Maybe the 450/400 is a significant step up in killing power without a bunch of recoil tacked on.No experience. Google search found this, for what it is worth. http://www.chuckhawks.com/rifle_hits_table_syn.htm
Just over 2000 H.I.T.S. For 300 gr 375 compared to 2400 H.I.T.S. For 400 gr 450/400.