I've got a Left Handed .375 Ruger Alaskan (matte stainless) with the grey laminate stock and I absolutely love it. It was my first foray into anything larger than a .308 and my main reason I choose it over the H&H was I wanted something that was more compact. The short action and the 20" barrel make for an incredibly fast handling rifle.
If I remember correctly, Ruger only made an original run of 100 or so of the Left Handed Alaskans so they were very hard to find and very expensive once found! Unfortunately, I decided I NEEDED it and paid a pretty penny...fast forward a few years and apparently Ruger decided to do another run so now they are much cheaper and easier to find.
Generally, I don't mind a right handed bolt for any other types of shooting. My .375 Ruger is the only left handed gun that I own, but for the purpose of the rifle (hunting) I wanted to be able to cycle the action without losing my sight picture like I do with the right handed guns.Being left handed is tough when it comessed to rifles. I paid considerably more for my CZ 550 in .375 H&H than I would have for a right hand model, but finally got a gun cheaper here recently. Appardently there are a whole bunch of folks looking for left hand .458 Lotts!