Lots of lefties in 7mm-08, starting with one of my favorite lines - Savage. Their model 16 Weather Warrior is available in 7mm-08. Also pretty sure that Tikka makes a lefty 7mm-08. I've been shooting Savage rifles for maybe 25 years, and I've never been disappointed with a single one. 280 Rem in LH, yeah, that's a challenge. I guess if I really wanted one, as would be the case with a 35 Whelen, I'd buy a 30-06 and get it "fixed."