I don't think there is actually a perfect chambering. For a pure PG hunt I am using something other than a .375 - not that it doesn't work well in that role. On those hunts I previously have used a .338, 300 Win Mag, 30-06, and .275 (7x57). All worked just fine. Force me to pick one and it would likely be the .338, though I could be convinced it was the .300 - or the '06 - or the .275.
I think the perfect rifle is more about the rifle itself and less about the actual round it shoots.
I agree.
I have personally evolved to thinking that the logical progression is something along the lines of:
.25 (OK, .275 was king) for light PG and most MG (mountain game)
.30 for most PG
.35 (OK, .375 is king) for Eland, Buffalo and carnivorous DG
.40 / .45 / .50 for large herbivorous DG
Whether it is .25/06 or .257 Wby, or .30/06 or .300 whichever Mag, depends on species and biotopes. For example .30/06 is perfect for dense cover Kudu, but .300 is more appropriate for open range Cape Kudu.
I did have my .33 period, and I still own a Dumoulin .338 and a Mark V .340, but I think that modern heavy weight bullets such as the AFrame or TTSX have really upgunned the .300 deeply into what was .338/.340 territory, although for close range deep forests Elk the .338 still reigns, and for longer range Yukon Moose the .340 still reigns, but I found them needlessly powerful in Africa for all but Eland, although there is no arguing that they bridge the .30 to .40/.45 power gap just as well as the .375 does, with better ballistics to boot.
Or for those who are having a fling with metric calibers, the same logic applies to 6, 7, 8, 9, 10 or to 6.5, 7.5, 8.5, 9.5
(OK, 9.3 is king), 10.5
