As for number of shots and ammo, I always shoot Federal Premium 300 gr softs and solids. The only buffalo that ever took more than one shot was the Banteng. Absolutely the toughest bovine I had ever hunted, it packed lead and kept coming.
This one, and the buff in my avatar were taken in Rungwa, Tanzania 2018! The first shot would have done it on either of them, but I keep shooting until I KNOW they aren't getting up!
The Cape Buffalo that I shot in the Metetsi region of Zimbabwe in 2005. I was hunting with Johan Spies, using my .375 RUM and a 300 grain handloaded Barnes TSX bullet. One shot through his shoulder. He ran about 50 yards and dropped. And an American Buffalo that I shot in Montana in 2006 with my Hawken muzzleloader shooting a 425 grain Maxi-hunter lead bullet. It was about a 50 yard shot, placed just behind his shoulder. The bull dropped, got up and ran about 20 yards, and fell dead. 500 pounds of great tasting hamburger.
