Mt $0.02 would be for the 25-06. It's been my go to for antelope for a long time now, despite the fact I have to shoot an ugly rifle to use it (camo synthetic abomination of a stock). One of these days I'll fit a proper piece of walnut on it. While not the hotrod the 257 Weatherby is, it will do everything needed, and do it well. Easy to find both factory ammo, or components for reloading. Available in LH versions from several makers. Really like my 250-3000 M99, but the 25-06 does add more reach if it's needed.
Btw, since using it for antelope was mentioned, only 1 of over 3 dozen antelope was shot over 250 yards. The majority between 100-200. Last one at 80. They can be snuck up on...