I am a firm believer in shooting until they drop, and if they move much on the ground I shoot more. That applies to anything I shoot.heavy 338 win mag and bigger. my advice is to shoot the heaviest caliber gun you can shoot comfortably and accurately. A wounded moose near water will try to make the water. And wounded moose already in water will try to go in the deeper water. if you can anchor them on dry land than your day cutting and hauling is going to be much more pleasant. I’m a big fan of the 416 with premium bullets when I hunt in Alaska.
The 416 Ruger and 350 grain TSX has performed well for me. It is one of my favorite combinations. I can say the same for the 375 Ruger and the 270 grain TSX. But, none have fell any faster than with the 338 Winchester and the 225 grain TSX. Instantaneous drop, without a spine or brain shot. just does not get any faster. Though, I have had as fast with the 375 and 416.
I do not expect that with any of them. But, I certainly like it when it does happen.