I would say the .375 has fallen into my backup gun niche for sure and I have backups to the backup.
1. For a cartridge so useless, they have a nasty problem of replication in the safe.
2. They are impossible to shoot with their heavy recoil.
3. Ammunition is overly spendy, unavailable and difficult to reload.
I have a TC Encore Pro Hunter and I just zeroed that for a rainy day hunting rifle. It has a Simmons 3-9x50 and it's super light. I have no desire to be tracking anything on a rainy day and the scope gathers plenty of light.
I have a Ruger 1-H with a Leupold VX-R 2-7x33. It's not as light, but it swings well on running game and has an excellent trigger. It's beautiful to look at and I enjoy hunting with it.
I have a Winchester Safari Express with either a Leupold FX-II 2.5 x Ultralight or a VX-3i 4.5-14x40 in Warne QD mounts. This is a big sized rifle and I like it for the accurate firepower it brings with it. I do not feel undergunned ever with it around. Would I like to make it a drop box magazine? Yes, but this rifle's future is uncertain.