Having owned a Safari Express in both 458 Win and 416 Rem. I'd say the weight is about right for those two calibers. Recoil is very similar between the two. Once a scope, 4 rounds of ammo and a sling are added, you're around 10lbs 12oz or so. Recoil is manageable if you do your homework. But I personally don't like heavy rifles. When hunting, you carry the rifle way more than you shoot it.
My current 458 Win is a Blaser R8 Profesional. All set to go with a sling, Nikon 1-4 scope, and 4 rounds of ammo, my weight is 10lbs 2oz. With a 23.5" barrel, the R8 is about the same overall length as a 20" standard bolt gun. Having a short overall length and a stock that fits me very well, this gun is both easy to carry, and comfortable to shoot.
I also use it with a Trjjicon RMR, which brings the overall weight down to 9lbs 2oz. Even set up like this, the recoil is very manageable.
IMO, if you need a muzzle brake to make a rifle shootable for you, then it's best to go down in caliber.