You're not going to believe this, but for most DG rifles, it makes no difference. The following are ballistic tables for a .416 caliber 400 grain TSX Barnes bullet at 2400 fps sighted in at 100 yards.
0 - 1.6" low (assumes a 1.6" scope mounting height)
10 - 1.16" low
20 - 0.77" low
30 - 0.45" low
40 - 0.19" low
50 - 0.00"
60 - .13" high
70 - .20" high
80 - .20" high
90 - .13" high
100 - 0.00"
150 1.72" low
200 - 5.28" low
So, out to 100 yards the most you'll ever be off is a bit more than an inch. For most distances it's good enough to hit an elephants eye (1.5" diameter) if you're steady enough. The brain is much larger than that. Inside of 10 yards the scope won't be helping all that much anyhow. Out to 150 yards, it's a dead-on hold for any PG animal (or wounded DG).
By random coincidence, 50 yards is the point at which the bullet crosses the reticle on its way up, before falling a bit back to zero at the 100 yard point.
If you still aren't convinced, sighting in at 50 yards gives you this:
0 - 1.6" low (assumes a 1.6" scope mounting height)
10 - 1.16" low
20 - 0.77" low
30 - 0.45" low
40 - 0.20" low
50 - 0
60 - .13" high
70 - .20" high
80 - .20" high
90 - .13" high
100 - 0.01" low
150 1.73" low
200 - 5.29" low
Maybe this diagram that I stole from the Internet helps. The bullet passes through the line of the reticle at 50 and 100 yards.
Sighted in at 100 yards, the same bullet at 2100 fps crosses the reticle at 38 yards and again at 100 yards, so it only holds perfectly true for the situation I presented. For most DG rifles, pick something else to worry about, like shooting technique, etc.
View attachment 701987