I reload to save money and for practice most of the time. I get my reloads as close as possible to the factory ammo that I plan to hunt with.
Right before the safari, I'll start shooting the factory loads exclusively, for practice.
I've had more reloads not function properly, than supreme factory loads (never), but that is probably my own fault in trying to save money by using older powder, cheaper primers, brass fired more than one time, a particle of brass polishing media stuck in the primer hole, discount bullets, etc.