Newboomer
AH legend
My 2 cents: Use a 30-06 with 180gr Barnes TSX. Good for everything up to and including eland.If I were to be shot with a .375, I’d much rather it be with a 270 grain InterLock than a 300 grain A Frame. I’d die quicker.
Tissue damage (what actually kills the animal) will be much greater with the lighter, faster, and softer InterLock.
The A-Frame will certainly have more of a penciling effect on smaller game, like the springbok, impala, and blesbok you mentioned having on your list. I think the 300 grain Swift A Frame, while considered the pinnacle by many (and for good reason!!!), actually reaches a point of diminishing returns on a plains game hunt in the Eastern Cape.
And 270 grains of lead is more than enough for your larger game, like the gemsbok and kudu you're after.
Side note: I'd personally swap out the gemsbok for a bushbuck since you're hunting the Eastern Cape. ( my two cents you certainly did not ask for)
I'd say you're probably better off just bringing a flatter shooting deer rifle that I'm sure you already have at home. The Eastern Cape can certainly call for some cross canyon shooting.
I found African plains game to be incredibly overhyped in terms of their "toughness." No animal is immune to being double lunged. Truth!