I've never wounded a 4 legged animal. A lot of that is for sure luck, I'm not going to sit here and pretend to be a "great shot" or anything like that. I think it's been a combo of having good shooting opportunities, at a reasonable distance, and practicing enough.
With that being said, I've only shot 7 four legged animals in my life.
Georgia
2 hogs killed with 1 shot from a 44mag carbine, 60-70 yds from a blind. Pure luck. They were standing right behind one another. Outfitter was happy I killed two because the property was overrun.
RSA
Blesbok - 1 shot, 300WM, down where it stood. 50-60 yds
Impala - 1 shot, 300WM, kicked up on its back legs and died in place. 60-75 yds
Kudu - 1 shot, 300WM, ran 50 ft and died. 100 yds or so.
Warthog - 1 shot, 300WM, ran 100 ft and died. 100-120 yds or so (my toughest shot, also killed a guinea fowl behind it)
Wildebeest - 1 shot, 300WM, ran 100 ft and died. 30 yds from a blind, not a hard shot.
I've actually shot a rifle 6 times for hunting purposes, and killed 8 animals.
I'm sure if I hunt long enough in Africa, and elsewhere, I am going to have to follow up on something. Guess I've been lucky.
Waterfowl...that's another story. Ducks are a lot tougher than they look. Lost a broadbill last season that I still have no idea how it didn't die.