In general, 300 yards. Most hunting I do is with a 30-06. For really big non dangerous game like moose the velocity past 300 is down enough I don't think it's got the energy to effectively kill one. My 300 Win Mag would give me more range. As for caribou, deer, kudu, etc. It gets to be a small target beyond 300, especially adding wind and I'm shooting off of either sticks or the top of my backpack frame in field conditions with my heart probably sped up more than at the range, so I'm not risking it.