Even when you take care to be sure there are no animals behind your target animal, strange things can happen. A couple years ago my son and I were tracking 3 Dugga Boys. My son approached the bulls with our PH, the bulls were spread out and my son shot the closest bull while it was broadside at about 50 yards, with the other bulls about 10-15 yards farther and off to the side. He was shooting his 375 H&H with 300 grain TSX’s. He shot the bull twice, with the 2nd shot being head on. The bull was down quickly and then our PH Alan Vincent began motioning for me to come up quickly. As soon as I arrived, Alan asked if I could see the buffalo standing behind some trees and to shoot it if I could. All that was visible was the shoulder so I sent a 400 grain Bearclaw into it. A few quick shots and that buffalo was down for good, going only about 20-30 yards.
When we were cutting up my buffalo, one of the trackers handed me a Bearclaw that was from my first shot. And then he handed me a TSX that came from the liver…. I hadn’t shot the buffalo midship at all, so was confused. Only after a bit did I realize it was a 300 grain 375 TSX. When my son shot his buffalo, the first shot was broadside. The bullet had exited at an 45 degree angle and hit my Buffalo standing behind and well off to the side. It hadn’t reacted to being hit, but also didn’t run away, which is why I was able to come up and shoot it.
TSX’s often exit, so extra care needs to be employed. I don’t recall having a Bearclaw exit on any Buffalo and they’re generally what I have in the chamber for my first shot.