I fell in love with the simplicity of the Ruger No. 1 and now own four. It's my favorite rifle to hunt with & while sitting in a stand, I have taken deer with them ambidextrously off both shoulders depending on which way I had to turn. I have a 6.5x55, 275 Rigby, 303 British & a 9.3x74r which are all excellent choices for hunting in the southeastern woods of the USA. I have two Winchester 1885's with long octagon barrels in 375 H&H and 405 Win but these rifles are not nearly as compact & nimble as my Rugers even if they are both fun to shoot.
While all of my single-shot falling-blocks are nice, I really like the ones chambered for a rimmed cartridge a lot. The rim makes it easy to grab the end of the bullet especially when wearing gloves or pulling it out of a cartridge holder. Loading the rifle with a scope over the breech is easy with a long cartridge so my No. 1S chambered in 9.3x74r is particular favorite. Ruger No. 1's can be a bit of a challenge to scope properly since you need more eye relief but my Minox ZA5 1.5-8x32 is an excellent choice on that rifle.
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My 9.3x74r ammo makes the 6.5x55 look tiny
Personally I like smaller scopes on these rifles so options similar to the Meopta R2 1-6x24 RD I have on my 303 British are a good choice to consider. I had a larger S&B Klassik on my 6.5 Swede for a while & to my eye it looked disproportionately big for the size of the compact rifle.
I briefly considered getting a larger bore Ruger No. 1 Tropical at one point. Because of my aforementioned penchant for rimmed cartridges, I was looking hard at the 450/400 as an option. I briefly got dragged into a bidding war on a rare 404 Jeffery because I love classic chamberings but the other guy was loonier than me so he prevailed. Eventually I settled on a left-handed bolt action 458 Win Mag in case I ever go up against anything big & dangerous. That doesn't mean I won't eventually own a larger Ruger No. 1 one day. Acquiring them can be addictive.