My introduction to it was reading of a certain rifle that was a fixer upper, hence why the .500/.416 may work for someone else.I'm gonna guess you don't like the 500/416 NE?
I was actually referring to the more common 416 cartridges such as the 416 Rigby and the 416 RM (but i still think the 500/416 is a fine cartridge).
In almost every African situation i would take a 416 RM over a 375 H&H but that is just a personal opinion.
The idea of the cartridge is a nice one. I'm not particularly interested in it though as I prefer something I can more readily find and in the case of the Lott, having a back up ammunition stream in a shorter chambering is not a bad thing either.