My recommendation would be for an AR-15. Here are some of the reasons why:
With respect to a wheel gun, I was trying to advise someone with little experience in "home defense" firearms. My spouse is competent and capable with her 686.Which is why I said "register it".
Whatever firearm you choose, whether handgun, shotgun or carbine be sure to get 1,000+ rounds of training and practice ammunition. Find yourself a good gunfighting school and get trained up properly and become competent and proficient with it.