That's a great question and depending on the shooter, there is no wrong answer. For probably 75% of scenarios, the scoped 375 is perfect and it makes a fantastic one gun safari. Many of us have done that exact thing with no regrets. If ele or hippo are involved, I go bigger just because it makes me feel better. Also, I like the 416 for lion but there is nothing wrong with 375 there. I've just seen a lion stay on their feet after having 400 grain softs run long ways all through the body from chest to rear. I was glad to have the 416 and it's always a little more insurance for who knows what. Also, I prefer a 416 on big eland. That's just me. I think every serious Africa hunter will get a lot of use from a scoped 375 or 416 on a variety of species.