So far, the largest caliber rifle I own is my Custom Brno 458 Lott with a fiberglass McMillian stock. I feel comfortable shooting it with 500 grain bullets at 2300 FPS and am very accurate with it. I do try and limit my shooting sessions to 10 rounds. This may sound silly but I honestly cannot tell the difference between my 458 Lott and shooting my CZ 416 Rigby and my Heym 416 Rigby.
Like others I’ve graduated to larger calibers over time. My first experience shooting the big bores was 30 years ago, shooting Winchester M70’s in 458 Win Mag and 416 Rem Mag and back then it was brutal! That was before I learned to protect myself with a PAST recoil pad and only shoot off the bench to sight in.
Back then I also considered the 338 Win Mag and 375 H&H pretty heavy recoiling rifles. Honestly the hardest recoiling rifle that was just flat out painful to shoot and I also have a permanent scar between my eyes from a scope cut, was my Custom Shop Remington 375 RUM, weighing only 7 lbs and maybe 7 3/4 lbs with scope. Even with a PAST recoil pad it was brutal like getting punched in the shoulder by Tyson. Shooting a 10-11 lbs 458 Lott, 458 Win Mag, various 416’s was a walk in the park compared to that lightweight 375 RUM!
So rifle weight and fit play a huge role. With all that said, I wouldn’t hesitate to hunt DG with a 375 H&H or 375 Ruger anytime, anyplace. But like others here, I just like the larger calibers, no I love them! 416 Rigby and 458 Lott are my favorites. I can definitely handle recoil better at 61 than 31 but I have lots more experience now.
Shot placement is everything but hunting elephant, a larger caliber like 458 Lott, 450 Rigby, 500 Nitro, and 500 Jeffery can give you an advantage. A near miss on an elephants brain with these big bores mentioned will knock it down giving you time for another shot, not so with a near miss with a 375, the elephant will be off and running.