Every PH I’ve hunted with says TSX all the way for buffalo. I’ve shot several buffalo with TSX in 375 and have always gotten plenty of penetration. This includes some really big Australian buffalo, which are even larger than Cape buffalo. In 416 caliber, you should get even more penetration I would think. But on the other hand, I would feel pretty good about having some CEB solids down in the magazine for going away shots on a wounded buffalo. That way you know without a doubt that you can reach the vitals from any angle. But in all honesty, I’d feel pretty good either way.