Agree with everything printed above. IMR (my fav) powders are temp sensitive, but not when going from a warmer climate to a cooler one! It's an issue for me living in the Appalachians heading to TX or Africa (but I typically find that backing off 0.5 gr on hot handloads does the trick-and it prints the same in country. Now, be more concerned about elevation differences when heading to Africa. You'd be surprised how many places are at higher elevation than Denver! On one trip to Namibia, everything was printing 4"+ high, but there are actually places in RSA/Namib/Zim that are 8,500-11,000 ft above sea level (and that has more pronounced effects on your sight-ins!!!) Many hunting areas are 4,500-6,500.