Only if you enjoy getting beat up! The No.1 design doesn't really lend itself to the big kickers... in my experience. Had a .450-400 and it literally would give me recoil headache, the only rifle that ever has. I would buy one in 7x65R or .348 Win if made. Currently have two, both easy kickers. The .275 Rigby Ltd Ed., and a SS walnut in .257 Roberts, also a ltd run. Neither are going anywhere soon.