Some thought should be given to the rifle this light, flat and fast cartridge will be fired in. To get the most speed out of the 257W, 25-06 and similar rounds a 24 inch + barrel and in the weatherby’s case, a magnum action is needed. If a heavier, longer rifle meets your needs then these rounds would be a good choice.
If on the other hand, you want a light portable rifle firing the light, flat and fast round the short action rifles with a 22 inch or shorter barrel would be appropriate. The 257 Roberts , 6.5 Creed, 6mm Creed, 6mm Remington, 6mm/308 (I used this name rather than .243 as to not offend Bob), 260 Remington …..My favorite rifle for spot and stalk is a compromise between the 2…it’s a Weatherby mkV light weight in 270 Winchester. It’s the 6 lug action with a thin barrel.
I think I’d focus first on the type of rifle I wanted then match the cartridge to the rifle. Tikka makes left handed rifles in a variety of calibers. I just saw that they make it in 6.5 PRC. - a 6.5 Creed on steroids.