Shooting "full Nitro loads" in a 577 BPE is like pulling the pin on a grenade every time it is fired. I would urge you not to encourage others to do something that dangerous. A typical .577 BPE is proofed to safely fire from 12k to 14K PSI. Some nitro for black powder loads run up to 18k PSI, but even that is inherently potentially dangerous and beyond proof. A .577 Nitro express load generates pressures of 33K to 40K PSI. That is creating a potential bomb out of a BPE rifle, I don't care how many buffalo your friend has killed with it.
The 577 BPE , like the 500 BPE, was not intended for thick skin dangerous game. That is not conjecture. It was a lethal lion and tiger choice. The barrels also were not intended for modern projectiles. Typical were relatively thin copper skinned or pure lead projectiles. Modern steel or brass jacketed bullets will quickly damage rifling, particularly in Damascus barrels with which many BPE guns were equipped (often now blacked which hides the damascus pattern).
Will a BPE kill a buffalo. Of course, if hit in exactly the right spot under exactly the right conditions. So did a 6.5 solid from Selous's H&H .256 Mannlicher fired by Bill Jones in the Zambezi Delta. That does not make the .256 a buffalo rifle.