I appreciate y'alls wisdom on this subject. I do have a better feel for what I was asking which was more or less everyone's general feelings about the cartridges adequacy for the task. It seems that a large majority of you feel it is easily up to the task. It appears that the opinion of it is closer to the 300 win mag of the elk world than the 270. Ha ha. I feel much more confident that should I happen into some buffalo and have my 375 in hand that it would handle the job easily. I just need to pack a few premium "buffalo" bullets for it and keep them with me. If it were not for the fact that I already have the 458 and a lifelong buddy of.mine sold it to me and very much wants me to shoot something in Africa with it then I might just take the 375 by itself. I think I can get them both in the same case though and put the scope for the 375 in my carry on so it's not that big of a deal. On a side note I do have a 350gr for that 458 that I can carry in case I happen into a PG animal that I desire while I have the 458 out. Honestly I'm very excited about this 375 H&H though. Never had one and it does seem like an extremely useful cartridge.