I used Woodleigh Hydro's 300gr in a Kimber 375H&H at Caprivi area in 2019, and with one bullet type shot Hippo, Wildebeest, Warthog, Dieker, Croc, Zebra... wound chanel was very good on all. Leupy VXR 3-9x40 scope was mounted forward as much as possible. I always take a pre sighted spare scope on my hunts. The second scope was a Leupy VXR 3-9x50 if needed for poor light, mounted back 3/8" from rings. Only hassle I had, was lying down to shoot the croc at 150yards, my shot was perfect into brain, but it was moving around, and outfitter was semi yelling shoot again, shoot again... so scope cut me 2 times, more blood on me than the croc... Obviously laying prone with 375H&H (and scope a touch closer) was the problem.
Last year I found a lovely old, AS NEW, Ruger 458 M77 and just yesterday found an (oldish) 3x Leopy, so scope is being posted to me, and with no power adjuster section, this can be mounted way forward. After hitting 60yo, my eye sight doesnt work as well on opens, and me I often forget to hold bigger rifles tight.. so occassionally scope comes back on me.
Back to your subject... I have seen many hunters shoot large calibers very well.. so.. 1/ any 458 WM caliber Buffalo bullet will kill the Leopard if you hit it properly... (wound it with any rifle and its angry, as is PH)... OR 2/ have a XXXXXX x50mm scope for the 400 grainers and the Leopard... and a XXXXXX scope for the 500 grainers for the Cape Buffalo, in your QD mounts.... OR 3/ also bring the ideal 30 caliber with XXXXX x50mm scope for Leopard... as a high chance a 200 yard shot (or further) on other game will happen on safari.
Ha... all this overthinking and sorting gear, is the half the fun.
My last trip last year to Caprivi, and then Plains game area, I took 404 Jeffery after Eli with Byron Hart, and 7x57 after Gemsbuck, Warthogs, Jackals, Steinbuck with Zana Boates... Had an awesome time. I could have used the 404 on everything... however this 7x57 is a lovely custom job I've waited on for ages, and it was nice to take shots prone or resting with ease.