Any reason not to use a 350 grain .375 bullet for buffalo

My home built .375 Weatherby does 2889 ft/s with a 300gr. I chronographed it. Long barrel. I throated it for a 350 and still left 3/8" of freebore. I've yet to load some 350's. Want to try them. Not sure what velocity I could get....maybe 2750 ft/s? That would be a real hammer. To date, it does so well with 300gr that I've not varied from that. Don't even intend to look at 270's. I just figured I'd run only 300's in it and that's that. But you guys have me thinking about 350's again :)
Jim, depending on how far you are trying to push them, you MIGHT even think about slowing that bullet down. It seems like I keep hearing (and I honestly know roughly nothing) that you want to be in a range of 2100 (and not under 2000) to 2300fps at point of impact.

I am 100% sure there are others on here that know more on this than I.
 
I sure hear alot about the greatness of the Woodleigh hydro bullets but i don't believe anyone is commercially loading them right now...i could be wrong. I know Mark Haldane almost requires use of a Swift A Frame for the first shot because they are shooting in herds and don't want over-penetration. I think the last time I heard he will pay if it over-penetrates and injures another buff. If you use anything else, it's on the hunter.
The woodleigh hydro has acted as I expect from a solid. I shot buffalo center of chest and we found bullet under skin on back leg. Adjacent swift is from a zebra. There are a lot of good solid choices, but the woodleigh hydros feed really smoothly in my rifle.
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