I would NOT consider using a 300 gr .338 on African DG in an '06 case. No way, no how! Maybe a 250 gr properly-selected modern bullet in a larger cased 338 for cats or croc. The OKH is NOT a DG gun. It's what we like to call, one of the first renditions of the "poor man's magnum," which it fails short of, but fine for NA game. Was it Gibbs that did such things prior to OKH? You could take a leopard or croc with it, but again, I'd channel Ruark! The 338-06 A-Sq is phenomenally accurate (as are all my .338s.) The 338 A-Sq is tied for 3 most accurate guns, ever, but the 06 will shoot <0.75" groups all day. Elk, black bear and deer is where it's at. There's a story in the Barnes manual about Chub Eastman being on a (moose I think) hunt and encountering a big brown bear, so he took it with the .338-06 he was carrying for moose (using 250 gr TSX) "and fell in-love with it." LOL NOT my 1st choice for coastal brown bear (but the bullet did the work at close range)!