I’ve used the .220 and .22-250 extensively on prairie dogs. At 400, I don’t find any practical advantage of one over the other. The Swift has slightly less holdover, but you’re holding over with both of them. Wind drift seems very similar. The trigger probably plays a more significant role in a hit at 400+ than 200 fps give or take. I bet you’ll love the .22-250AI. Personally I wouldn’t ream out a good shooting rig to get one, but if you’re starting from scratch it’s as good as the others.
Played rookie league for the Yankees in Paintsville after winning the College World Series at Fullerton State, in1979. All I could think about was the movie “Deliverance”- lived up in a hollow with some other players. Refused to go on a moonshine run because it was a dry county-no way. Met some of the nicest people on the planet there! Van Lear the home of Loretta Lynn was highlight of summer LOL.
Mule deer and Colorado elk seasons almost done! Hunters driving farm roads, looking for racks, their PH driving them along, I ask that you not pull into my drive. The buck behind me, on the boundary line of the GMU somehow knows. The hunter laughs, I would invite you in to see my Searcy rifles but social distancing prevails, darkness arrives and the buck slides away into secret tree grove...