I used the ELDX with success in a 6.5 Creedmoor on Black Wildebeest and smaller.
I shot a whitetail last fall with an ELDX, but from a 28 Nosler at 150 yards. Speed was likely around 3060 at impact. The bullet went in behind the shoulder, exploded and didn't make it to the far shoulder. Deer jumped and ran off, one drop of blood and he was piled up about 70 yards away with soup for insides. He was dead, but I think I would pick something stronger if I were to use that rifle at that distance/velocity again.
If I were you, I would take the 375 as others have mentioned. Plus, it’s more class for an African hunt, and that’s half the battle.