I've had great success with 5744 with .375, 450-400, .458 and 9x57 with lighter bullets. Sadly I can't get it to work in my .450. However the old nitro for black formula works great in the .450...just have to use a filler.All the Big Bores - or for inclusivity's sake, let's just say "375H&H and up" - with the right amount of AA 5744 can be loaded down to "deer load" velocities and still be accurate. I've done that with handloads for my .375H&H and 200grn bullets for a few deer camps, and still want to do a deer camp with my .404J.
I also definitely want to smash some feral hogs with my .404.