I have shot all kinds of bullet mfg's and weights out of my 375H&H just haven't had the opportunity to hunt anything larger than groundhogs. 250gr Sierra's are excellent for accuracy. Personally I have talked to individuals and read articles on Hornady Interbond bullets. General consensus seems to be that they have disappointed more than they have been liked. Of course you will have those who disagree but just going by general consensus. Barnes seem to be the bullet of choice for quite a few. Haven't had the opportunity to use them myself. I would agree that the Woodleighs, and Nosler Partitions are a great choice of bullet.I have not tried Sierra before but I hear good things about them. Good luck this fall!