I'm more of an AND kind of guy. If I were doing what you are doing I would load some 250 grain barnes ttsx for the plains game. It shoots just about as flat as a 300 win mag with 4477 ft lbs of energy at the muzzle and top it with a 2x12 vx 6 if it fits without hitting back sights.
I'd then load up a bunch of 300 gr tsx for the buffalo and have my 1x6 vx6 for buffalo.
I think you mentioned you had Talley QD mounts. You can have the best of all worlds this way.
I used a Leopold VX6 1-6 on the Sako 375 HH I rented in Africa. Longest shot kill was 140 yes. I took a shot in brush at 185 yes but had it deflected & missed. I felt no handicap. I just ordered a Sako Kodiak 375 & plan to put a Trijicon Acupoint 1-6 with the single post & green tritium triangle.
Hi Bob, how's things going in Wyong?. Down your way a couple of years back but haven't been in NSW since Ebor for the fishing. just getting over some nasty storms up here in Qld, seeing the sun for the first time in a few days. I'm going to NZ in the spring and hope to clean up a few buns while there and perhaps shake the spiders out of my old .303LE (currently owned by my BIL). Cheers Brian