Hi Guys, I am trying to combine my main hunting rifle with my "dreams of Africa" rifle, and want advice on cartridge. It will absolutely be one of the two I've posted in the topic. For hunting in the US, I will be using cast bullets and significantly downloading the cartridge. It will be somewhat like a trapdoor 45/70 in that respect. For larger game, the sky will be the limit. I see lots of financial advantages to select .375 over the .416, but as a large-caliber junkie (my current dreaming-of-Africa rifle is a .510 caliber) there is a tic in my head that says I am better off selecting a .416, even though it means that all other shooting will be more expensive. And yet, I see plenty of threads here of folks who have taken a 375 Ruger to Africa for their Cape Buffalo (which is my African Dream). So I have to ask those who took a .375 to Africa for buffalo, am I being overly worried over something that may not happen in the next decade, and that if I get my lifetime chance to go to Africa, that 375 will take a Buffalo just as cleanly as a 416 given proper bullet and load selection? Or is there enough of an advantage to the .416 for the case of very large game, that I should consider it more strongly over the 375, knowing that it will be more work to get it running well for all non-very-large game shooting? Opinions? Am I agonizing over nothing?