All the above comments are spot on. It's always good to shoot what you are most accurate and comfortable with. 350 or 400 grains will not make much difference with proper shot placement.
Gentlemen - Shot placement is the key deciding factor of success. .375 H&H will drop any buff given the hunter puts the bullet where it belongs. Love the 40 calibers but it'd difficult to argue against the "Queen" of Africa.
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