A .375 Ruger at 50 yards - 250 grain Barnes TTSX 69.3 grains of RL15 - 2581 FPS, 3,698 FT-Lbs. fired from 20" barrel. This is the exit wound. Even on a "soft" deer at 50 yards, it expended just fine.
Only one data point, so statistically insignificant, but perhaps a start to the conversation.