I've used my .375's to kill moose, elk, and black bear. It's not traditional choice in the Canadian bush, but is not out of place either. The longest shot I ever took at a moose was 300 long steps away. I was hunting near home. The simple 300 gr. RN bullet from a Federal factory load did the job very decisively. The big and very old cow had some of the toughest meat I ever ate! Too bad those big bullets don't tenderize them some.