I have hunted cape buffalo only once. My rifle is a Ruger RSM .404 Jeffery converted from an original .375 HH with a PacNor barrel. My son's hand load was an original load to my knowledge. Barnes 400 grain TSX, powder 72 gr IMR 4064, primer CCI 250, COL 3.50 with Hornady brass moving at 2150 FPS. One shot kill at 90 yards. Bullet enter low center chest and was recovered from the stomach full of fresh eaten grass.