For leopard hunted over bait from a blind, I would use a non-bonded, mechanically locked soft-point bullet (Remington Core-Lokt, Norma TipStrike, Hornady InterLock), weighing 160–180 gr, in a non-magnum cartridge such as the 7mm-08 Rem., 7×57, .308 Win., or .30-06 Sprg...so I voted 7mm-08 Rem...