.375 H&H is my favorite cartridge. Used it almost my entire adult life after graduating from the .303 I grew up with.
For a while in my early 20’s I worked on a farm in Botswana for my uncle, and a lot of my job was shooting impala to sell to the local butchery. My working gun was a really nice Howa .223, and for head shots on impala, great gun.
But when we went hunting proper, shooting meat for the pot in camp, and used a .223 for boiler room shots on impala, we found the bruising to be horrific. So much meat wasted. Mind you, 90% of our shooting is within 75m, walking and stalking, so that high FPS flat shot from the .223 is not put to best use.
So started using the .375 for impala. Much less bruising and the impala drops on the spot every time. And of course, used it for eland, kudu and other bigger stuff too.
So yes, .375 is my do everything gun.