I'm just back from my second plains game safari in SA and already planning my next trip. It will be for buff and (four of) the tiny ten in Moz. About 90% sure I've picked the outfitter after meeting the two finalists at DSC this year that I'd researched. Guessing that buff will be on my list a lot going forward. Does anybody only hunt buff once?!? I have a 375 H&H that I shoot pretty well. It's a CZ with the Aramid stock, and I've had loads of work done to it to get it exactly like I wanted - slicked up for perfect feeding, Timney trigger, good 3 position safety, cerakote. It's comfortable to shoot. It's plenty accurate with factory ammo, and I haven't even started handloading for it. But when I was in SA in 2017 I tagged along for a couple of buff hunts. One was shot with a 300 grain slug from a 375 , while the second was shot with a 400 grain 416 slug. The reactions were pretty different and got me thinking about a 416 for buff. So, talk me out of a 416. 375 is plenty of gun for buffalo, right? Sure it is. But would it be your first choice for buff? I need a new rifle/caliber like I need another hole in my head.