This is a very good question. You see I purchased a double rifle, Merkel 470 NE, but had no intention of scoping it. So knowing that I might well be faced with a long shot on the hippo as well as other game my fall back was the Ruger #1 in 375 H&H. This rifle has a Luepold Scope with the custom dial. Having taken this rifle to the range several times I found that I could cut the bulls eye at 100 yards with ease because it loves the Federal Premium Bear Claws. Don’t ask me why it just shoots spot on with that ammo and scope combination. So accuracy on a hippo hunt to me was most important given that I missed twice last year. Also the 375 is a fine round for plains game where as that 416 can rip some game apart.
Don’t get me wrong I still love the 416 Guide Gun and I wouldn’t hesitate to use it in Africa or any place else. I guess I am blessed to have options on guns to select from.